New research indicates that people who come off blockbuster weight-loss injections like semaglutide or tirzepatide can put back on shed pounds far faster than those who end conventional lifestyle plans.
Research printed in a major health publication points out that while overweight people can lose about a fifth of their total mass while on the medication, the weight is regained at an average rate of 0.8 kg per month once they quit.
"People buying such treatments need to be cognizant of the potential of quick weight regain when the treatment ends," warns expert Dr. Susan Jebb.
That rate of recovery means a return to starting mass in about a year and a half.
Analyzing Approaches
The study, which reviewed dozens of studies involving over 9,000 of participants, contrasted the outcomes of GLP-1 agonists with conventional dieting.
Researchers point out that individuals who shed pounds through diet and exercise generally experience a slower weight regain—around 0.1 kg a month—post-intervention.
The Reason for the Quick Regain
Experts suggest the way of the injections accounts for the heightened regain.
These medications mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than normal could lead to the system to generate a reduced amount of its endogenous hormone, and could diminish sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication results in hunger is no longer kept in check, making binge eating a significant risk."
A Lifelong Disease?
Health authorities advise the injections for individuals with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts contend that, considering the high risk of relapse, the therapy might need to be long-term.
This opinion is echoed by pharmaceutical companies, who say that the results "underscore the long-term nature of excess weight," akin to managing diseases like high blood pressure.
Patient Accounts
People who have come off the medication report a sudden return of appetite.
"It was like a trigger flipping and you become starving," said an individual.
This challenge is compounded if individuals have not adopted lasting dietary or behavioural changes during treatment.
Widespread Adoption
Survey data show that a significant number of people in the UK have used weight-loss jabs in the past year, with interest continuing to grow.
- Adoption is greater among females compared to males.
- The middle-aged age group shows the highest usage rates.
- A large proportion obtain the drugs through private healthcare rather than public health services.
In conclusion, experts emphasize that while GLP-1 drugs are effective tools for shedding pounds, they are not a standalone solution and lasting health benefits relies on combined behavioural changes.
